Core Product Features
Discover how BioCode's innovative tools transform the genomic analysis landscape.
🔬 DONORmatch: Intelligent Donor Selection
Optimize egg donor selection with our advanced genomic matching protocol. DONORmatch goes beyond standard screening, using WES/WGS to ensure the safest genetic pairing for prospective parents.
- Comprehensive Genomic Analysis: We sequence the whole exome (WES) or genome (WGS) of both the donor and the prospective father.
- Advanced Compatibility Algorithm: Our proprietary algorithm cross-references genetic profiles to identify any shared pathogenic mutations.
- Maximized Safety & Success: By preventing high-risk pairings, DONORmatch enhances the safety of the IVF process and optimizes success.
⚙️ How It Works
DONORmatch is a combinatorial genomic protocol that optimizes the selection of egg donors for couples undergoing IVF. Instead of relying on limited checks for a few genes, it utilizes Whole Exome Sequencing (WES) or Whole Genome Sequencing (WGS) for both donors and prospective fathers, allowing for complete analysis and combined genetic risk assessment.
Genomic Mapping and Database Creation
Each donor and prospective father undergoes WES or WGS, generating a list of pathogenic or likely pathogenic mutations. All donors are included in a genetic database, where their complete, anonymized profile is stored. This allows every man tested to be "matched" against the entire database.
Combinatorial Compatibility Algorithm
The DONORmatch algorithm analyzes all possible genome combinations (man-donor) to identify where there are common mutations in the same gene (increased risk for the embryo) and which combinations are genetically safe.
🧠 Real-World Examples
🧩 Cystic Fibrosis
Today, many programs exclude women who are carriers of the CFTR mutation (cystic fibrosis) without considering the male partner. For example, if Donor A has a CFTR mutation but Male B does not, the combination is perfectly safe. DONORmatch allows for this combinatorial assessment, keeping the donor in the pool and only excluding dangerous matches.
🧠 Rare Neurological Diseases
Conversely, women who have not been fully tested may carry rare mutations for conditions like epilepsy or muscular dystrophies. With DONORmatch, comprehensive WES/WGS analysis identifies such cases in advance, preventing the creation of embryos with increased genetic risk.
💡 Technological & Clinical Benefits
- Complete transparency and safety in donor matching.
- Maximum utilization of available donors (no unnecessary exclusions).
- Personalization for each prospective couple.
- Automatic combinatorial screening of thousands of genes and variants.
- Continuous improvement of the compatibility algorithm with each new sample.
Comprehensive Data Management
From patient intake to final report, BioCode provides a single, organized hub for all your data, ensuring clarity and traceability at every step.
- Patient Record Management: Create, search, and manage detailed patient profiles with clinical information.
- Genomic Analysis Tracking: Meticulously track each genomic analysis for a clear, auditable history.
- Automated Data Processing: A powerful "Genome ETL" worker processes and integrates raw data, saving time.
Advanced Analysis & Diagnostics
Leverage powerful automated analysis and diagnostic tools to move from raw data to actionable insights faster than ever. Customize your analysis with flexible gene panels.
- Targeted Gene Panel Analysis: Create custom `GenePanels` for targeted analyses relevant to specific diseases.
- Automated Diagnostic Assessments: Run automated workflows to suggest potential diagnoses.
- Detailed Variant Management: Manage individual findings, allowing clinicians to review and classify each genetic variant.
Robust Reporting & Data Export
Generate professional, comprehensive reports at the click of a button. Easily export your data for collaboration, research, or integration with your existing LIMS.
- Custom Report Generation: Generate and retrieve detailed reports based on analysis results.
- Flexible Data Export: Export data in various formats (e.g., Excel) for easy integration with other tools.